After seventeen years in prison, the former respected Parisian banker Paul Lavond flees with his friend, the lunatic scientist Marcel that is researching with his wife Malita the miniaturization of animals and human beings to improve the resources of mankind. Paul Lavond was framed for robbery by his scoundrel associates Emil Coulvet, Charles Matin and Victor Radin that had stolen his business while his family was doomed to shame, poverty and tragedy. When Marcel reduces the retarded servant Lachna, he learns that the woman is motionless and only responds to the control of his brain and has a heart attack. After the death of Marcel, Paul Lavond sees the chance to use the miniaturization process as instrument of vengeance and he travels to Paris with the insane Malita disguised of Madame Mandilip, a nice old lady and owner of a dolls store. Paul Lavond, using the identity of Madame Mandilip, befriends his resented and estranged daughter Lorraine Lavond and plots a scheme to revenge and vindicate his family name.
In the small town of Peckham, California, many men die for excessive effort during sexual intercourse. When a scientist from the Brandt research laboratory is found dead in a motel, the government sends Agent Neil Agar (William Smith) to investigate the mysterious deaths. He suspects that the deaths may be related to some experiments of Dr. Susan Harris (Anitra Ford), who is researching bees in the Brandt facility.
Dr. Samantha Goodman, an attractive psychiatrist in her thirties, joins her husband and sister for a weekend at a winter cottage when an unexpected guest arrives. Harlan Pyne, a violent sexual offender, is convinced that Samantha conducted unethical experiments on him while she was his doctor. With the assistance of his troubled yet eager protege, Harlan forces Samantha and her family to participate in a series of nightmarish games. On this night of terror, escape is not an option, truth guarantees nothing, and revenge will not necessarily be sweet.
